Pharmacokinetics and Phenomenology of Inhaled Salvinorin A in Humans - Matthew Johnson

Salvinorin A acts as a potent and selective kappa-opioid agonist when inhaled, producing distinct psychedelic states characterized by feelings of directionality and intense spiritual experiences. Clinical findings show a clear, dose-dependent relationship between the amount of Salvinorin A administered and the intensity of the subjective effects reported. Rigorous study procedures, including double-blind, placebo-controlled methods, demonstrate that this compound can be administered safely to motivated, prepared participants in a medical setting. Notable results include high correlations between plasma concentrations of the substance and the intensity of reported subjective phenomena, suggesting a predictable pharmacokinetic profile for this unique agent.