Microdosing Results and Plasticity: A Prequel - David Erritzoe

Microdosing involves taking small, sub-perceptual doses of psychedelics such as psilocybin or LSD on a regular schedule. While many proponents report improvements in energy, focus, and mood, observational data and recent studies highlight the significant role that expectation and placebo effects play in these outcomes. A landmark self-blinding citizen-science trial revealed that perceived benefits in well-being and anxiety were not significantly different between those taking active microdoses and those taking placebos. Further neuroscientific studies are aimed at investigating whether repeated low-dose exposure can lead to neuroplasticity and therapeutic shifts in reward-processing networks.