Hamilton Morris describes the history of 5-MeO-DMT

5-MeO-DMT is analyzed as a distinct chemical entity with its own history and biological source in the Bufo alvarius toad. The substance was synthesized chemically long before its natural existence was formally described, and current data shows significant variation in potency among different toad secretion samples. This makes standardized dosing extremely difficult compared to synthetic alternatives. Ethical concerns surrounding the harvesting of Bufo alvarius toad secretions are addressed, highlighting how human interference and collection practices create severe stress and ecological dangers for the toads. Synthetic production of the compound provides a more consistent, ethical, and sustainable alternative, allowing researchers to avoid reliance on the fragile populations of these animals.