Lysergamides, LSD & Ergot with Paul Daley | Psychedelic Chemistry Part 2

Lysergamides are described through their historical, biological, and pharmaceutical lens. The discussion covers the origin of ergot alkaloids from the fungus Claviceps and their early use in midwifery due to oxytocic uterine effects. Emphasis is placed on the shift from historical ergotism to the development of synthetic pharmaceuticals, particularly LSD-25. The presentation highlights the importance of stereochemical configuration for biological activity, and addresses the historical context of clinical research alongside chemical refinement processes. The overview concludes by detailing contemporary exploration of newer LSD variants for both legal research and the grey market, illustrating ongoing scientific curiosity about these complex molecules.