Magic mushrooms rewind aging in mice - could they do the same for humans?

Psilocybin, through its active metabolite psilocin, is reported to slow cellular aging and improve lifespan in preclinical models. In human skin and lung cells, researchers found psilocin extended cellular lifespan by more than 50%. In aged mice, a long-term dosing schedule of psilocybin was associated with higher survival (about 30% increase) and healthier physical aging markers like improved fur quality, fewer white hairs, and hair regrowth. The proposed biological rationale includes reduced oxidative stress, improved DNA repair responses, and preserved telomere length. The work suggests psilocybin may influence systemic aging processes via serotonin receptors and motivates further study of psilocybin effects in older adults.