New Cannabinoids and Chlorin-Type Metabolites from the Flowers of Cannabis sativa L.: A Study on Their Neuroblastoma Activity

Cannabis sativa flowers yield new cannabinoids plus chlorin-type metabolites that show activity against neuroblastoma cells (SK-N-SH). Researchers isolated 11 compounds from flower extract, including two new compounds (cannabielsoxa and a hydroxypheophorbide ethyl ester) and chlorin-type compounds including pyropheophorbide A, a hydroxypheophorbide ethyl ester, and ligulariaphytin A. The study also reports six known cannabinoids. Biological testing used MTT assays for cytotoxicity in SK-N-SH cells, and docking analysis was used to support antitumor potential. Reported findings indicate cannabinoid compounds inhibited neuroblastoma cells more strongly than the chlorin-type compounds, and compounds 4-10 were highlighted as candidates for antineuroblastoma development.