Low-dose psilocybin reduces weight gain and hyperglycemia in mice on an obesogenic diet

Low-dose psilocybin can reduce weight gain and improve blood sugar outcomes in mice fed an obesogenic diet. In the reported study context, the treatment was associated with less body weight increase and reduced hyperglycemia compared with diet-fed controls, suggesting effects on metabolic regulation beyond appetite. The work frames psilocybin as a potential metabolic modulator, with results aimed at motivating further research into mechanisms and the translational relevance for obesity and diabetes risk. Limitations to animal data are implied by the preclinical setting.