The Science of Microdosing Psychedelics: Research History, Tolerance, Toxicity and Placebo Effects

Microdosing psychedelics is presented as a subject with a substantial but largely overlooked research history, rather than only a recent media trend. Torsten Passie’s book examines historical studies of microdose, minidose and low-dose LSD, along with research on other psychedelics. It addresses claims that microdosing may enhance creativity, elevate mood or help combat depression, while focusing on tolerance, toxicity and placebo effects. The book also includes newly translated LSD studies that had not previously been referenced. Its stated purpose is to provide researchers, practitioners and interested readers with a carefully researched account of the evidence and unresolved questions surrounding low-dose psychedelic use.