Ergot Alkaloids, LSD, and Psychedelic Science: Albert Hofmann on History, Chemistry, Therapy, and Indigenous Knowledge

Albert Hofmann’s book traces ergot alkaloids from the botany and cultivation of the ergot fungus through medieval poisoning epidemics, early medical applications, and pharmaceutical research between 1816 and 1961. It covers the synthesis of ergotamine and the emergence of lysergic compounds including lysergic acid and LSD, placing these developments within experimental psychiatry, psychotherapy, and consciousness research. The work also connects chemical and laboratory perspectives with Indigenous ceremonial and healing traditions involving peyote, teonanácatl, and ololiuqui. With 256 pages and a publication date of October 10, 2023, the book presents a historical and scientific account of psychedelic research while emphasizing the continuing significance of sacred medicines and ancestral knowledge.