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Five Lesser-Known Psychedelic Harms: PISD, Ketamine Bladder Syndrome, Kambo Swelling, CHS, and Wood Lover's Paralysis

Fireside Project Blog · Aug 29, 2025
Open on firesideproject.org
TL;DR

The discussion highlights five less familiar harms associated with psychedelic practices and related substance use: Psychedelic Iatrogenic Structural Dissociation caused by poor preparation, inadequate facilitation, or boundary violations; ketamine bladder syndrome linked to repeated or high-dose unsupervised use; temporary facial swelling known as "Frog Face" after Kambo; Cannabinoid Hyperemesis Syndrome from heavy, prolonged cannabis use; and temporary paralysis reported after consuming certain wood-growing psilocybin mushrooms. It emphasizes trained and ethical facilitation, informed consent, medical awareness, species knowledge, preparation, and integration as harm-reduction measures. The guidance also urges prompt medical attention for severe symptoms and identifies Fireside Project's hotline and coaching services as sources of support. Several mechanisms, particularly PISD and Wood Lover's Paralysis, remain uncertain or under-researched.

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Published Aug 29, 2025 · Added Oct 11, 2026