Psychedelic-assisted therapies face blind spots around neurodivergence, as autistic and ADHD people may respond differently to set, setting, integration, and clinical norms

Psychedelic-assisted therapies may overlook neurodivergent people, especially autistic and ADHD participants whose sensory processing, communication styles, trauma histories, and regulation needs can differ from standard clinical assumptions. Screening, preparation, dosing environments, and integration practices may therefore work unevenly or create avoidable distress when care models are built around neurotypical norms. Neurodivergence changes how set and setting are experienced in practice. Sensory overload, masking, difficulties with interoception, and different responses to touch, eye contact, or directive therapeutic styles can shape both acute sessions and aftercare. Trauma and social marginalization can further complicate consent, trust, and meaning-making. More inclusive psychedelic care would adapt protocols rather than treat neurodivergence as a side issue. Flexible preparation, clearer communication, individualized sensory accommodations, and integration that respects different cognitive and emotional styles could improve safety, access, and therapeutic benefit across clinical and nonclinical settings.