Appendix No. 26 compiles health conditions, medications, and psychedelics that can create dangerous interactions or require added caution before use

Health conditions, prescription drugs, and psychedelics can interact in ways that raise medical and psychological risk, especially around cardiovascular strain, serotonin activity, seizure threshold, and psychiatric vulnerability. Appendix No. 26 centers on practical screening and caution for people considering psychedelic use while living with chronic illness or taking medication. The focus includes combinations that may be contraindicated, situations that call for medical oversight, and risk factors that can make an otherwise common substance more dangerous. Psychedelics named in this context include psilocybin, LSD, MDMA, ayahuasca, ketamine, and ibogaine. Harm reduction is the main purpose. Safer decision-making depends on checking diagnosis, dosage, drug-drug interactions, and personal history rather than treating psychedelics as universally safe or universally unsafe.