Your brain on drugs: different psychedelics work in surprisingly similar ways - Nature news on brain network changes across psilocybin, LSD and ayahuasca

Psychedelics such as psilocybin, LSD and ayahuasca can produce strikingly similar effects on brain networks. The analysis combines hundreds of brain scans to compare how these substances alter connectivity among key brain areas. Rather than each drug causing completely distinct network changes, the findings point to shared patterns of network disruption. The report frames this as evidence that different psychedelics may converge on common neural mechanisms, which could help unify how researchers think about psychedelic brain effects and inform future psychedelic science.