The Neural Fingerprint of Psychedelics: Mega-Analyse mit BOLD Consortium zeigt geteilte Konnektivitaets-Signatur und REBUS-Validierung

Psychedelics show a shared “neural fingerprint” in resting-state fMRI, based on a BOLD Psychedelic Consortium mega-analysis that pooled raw rsfMRI data from 11 datasets across five countries. The study reports robust increases in between-network connectivity between transmodal systems (like default mode and frontoparietal networks) and unimodal systems (visual and somatomotor). It also finds stronger involvement of subcortical structures, especially striatal regions (caudate and putamen), along with cerebellar changes, shifting emphasis beyond purely thalamus-centric models. Within-network effects are selective rather than globally disruptive: Bayesian results suggest weak-to-moderate, drug and network dependent reductions, reframing psychedelics as adaptive reconfiguration instead of network dissolution. The findings support the REBUS model by showing a “flattened” predictive hierarchy, and they include drug-specific patterns while anchoring effects to 5-HT2A receptor distribution. Clinical implications include benchmarking new compounds, dose optimization, and linking connectivity changes to therapeutic outcomes.