Stephens Rehen: Biological Effects of Ayahuasca in Human Neural Stem Cells & Minibrains

Human neural stem cells and brain organoids reveal molecular mechanisms behind the effects of ayahuasca and its compounds. Research findings indicate that harmine promotes neurogenesis by inhibiting the DYRK1A enzyme, while 5-MeO-DMT impacts processes related to cellular plasticity and memory, and suppresses inflammation-related pathways. These studies contribute to understanding the potential therapeutic value of psychedelic compounds in addressing mental health and neurological conditions. By utilizing human-derived tissue models, neuroscientists can observe real-time developmental impacts and proteomic changes, bypasses traditional ethical hurdles associated with clinical research while providing nuanced insight into neuron growth and synaptic connectivity.