John Hartberg: Ketamine’s Therapeutic Potential: Practical Considerations

Ketamine demonstrates therapeutic potential for treatment-resistant depression in clinical settings, often when utilized as a sub-psychedelic oral lozenge in conjunction with standard psychotherapy. This administration route offers increased patient comfort and accessibility compared to intravenous or intramuscular applications while maintaining effectiveness. Patient monitoring remains a critical aspect, and research indicates that repeat dosing over time helps maintain positive outcomes, though relapse risk persists. Consistent data shows significant reductions in hospital stays and admission frequencies among participants receiving this therapy. Future research aims to further refine best practices, address dosing variability, and deepen the understanding of how this treatment integrates into broader mental health care protocols for severely affected individuals.