Carla Nasca: Epigenetic Predictors of Post-Traumatic Stress Disorder & Intervention Possibilities

Epigenetic mechanisms contribute to individual susceptibility to stress and post-traumatic stress disorder. Stress increases glutamate levels in the brain, leading to negative structural changes such as reduced dendritic length and spine density. Acetyl-L-carnitine emerges as a promising therapeutic agent given its role in modulating glutamate receptors like mGlu2 and correcting stress induced behavioral and neuronal alterations. Research findings underline the importance of mGlu2 in specific brain regions as a potential target for therapeutic intervention, potentially offering new strategies for managing depression and PTSD symptoms.