Ignacio Carrera: Ibogaine & Neurotrophic Factors: GDNF, BDNF, and NGF Releasing Properties

Ibogaine research focuses on its ability to release neurotrophic factors that promote the maintenance and repair of neurons in the adult brain. Its anti-addictive properties are being investigated in relation to GDNF and BDNF expression within the mesocorticolimbic dopaminergic system. Experiments in rats show elevated levels of GDNF in the ventral tegmental area and substantia nigra 24 hours after treatment, suggesting a potential long-lasting mechanism for reduced drug cravings. Developing novel ibogaine analogues aims to maximize this therapeutic impact while avoiding potential cardiotoxic side effects associated with the original compound.