Peter Addy: Therapeutic Potential of the Plant Salvia Divinorum

Salvia divinorum acts as a potent selective kappa opioid receptor agonist with research suggesting a complex profile that involves the brain reward circuitry. Evidence points to its potential in reducing addictive behaviors by counteracting dopamine increases typically induced by substances like cocaine. Studies reveal that salvinorin A influences interoception, or the awareness of bodily states, in a dose-dependent manner. High doses often disrupt the ability to sustain attention to bodily sensations, whereas lower doses may enhance a person's trust in their own body as a safe, cohesive entity.