Franz Vollenweider: 5HT2A Receptor Agonists & Mood Disorders - Mood, Empathy & Social Pain

Psychedelic 5-HT2A receptor agonists are examined for their potential to enhance mood and empathy while reducing social pain in healthy humans. By analyzing molecular and neurocognitive mechanisms, the research explores how these substances influence brain networks and behavior. Studies illustrate that psilocybin interacts with the amygdala, reducing its activity in response to negative stimuli, which aligns with reports of improved mood and social connection. Furthermore, these substances strengthen associative learning and stimulate neuroplasticity via glutamate release, providing a scientific basis for their therapeutic application in mood disorders.