Behavioral, Neurochemical, and Pharmaco-EEG Profiles of 2C-B in Rats - Tomas Palenicek

2C-B is analyzed through a multi-faceted study on male Wistar rats to determine its pharmacokinetics, behavioral impacts, and electroencephalographic profiles. Research highlights that 2C-B quickly crosses the blood-brain barrier and accumulates in lipophilic tissues. Its behavioral profile reveals a biphasic effect on locomotor activity and a significant disruption of sensorimotor gating, which is measured via the prepulse inhibition of acoustic startle. Neurochemical investigations demonstrate that 2C-B promotes the release of dopamine, serotonin, and glutamate in the nucleus accumbens and medial prefrontal cortex. Comparisons to MDMA, LSD, and other hallucinogens suggest that 2C-B exhibits a stronger hallucinogenic character than entactogenic properties. These findings offer critical data on 2C-B actions at specific receptor sites, including 5-HT2A and 5-HT2C, and its interaction with dopamine transporters.