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San Francisco Veterans Affairs: Treating PTSD with MDMA-Assisted Psychotherapy

MAPS · Jun 28, 2012 · Michael Mithoefer
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TL;DR

MDMA-assisted psychotherapy for treating PTSD is outlined as a therapeutic approach centered on supporting patients through internal experiences rather than directive conditioning. Therapeutic sessions prioritize maintaining internal focus under professional supervision, with integration sessions used to process difficult emotions, rage, shame, and fear. Initial findings from clinical trials indicate that MDMA treatment significantly reduces symptoms of treatment-resistant PTSD compared to placebo groups by helping patients overcome emotional numbing, fear, and defensiveness. Therapeutic outcomes show substantial drops in CAPs scores, and long-term follow-ups suggest that these improvements are often sustainable over several years.

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Published Jun 28, 2012 · Added Mar 31, 2026