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Hamilton Morris synthesizes 5-MeO-DMT

Hamilton Morris · Jan 9, 2021 · Hamilton Morris
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TL;DR

5-MeO-DMT can be synthesized in an inexpensive, toad-free, and sustainable manner, offering a viable alternative to the ecological exploitation of the Sonoran Desert toad. The process utilizes 5-methoxytryptamine and formaldehyde to create an imine intermediate, which is then reduced with sodium borohydride to achieve the final product. This method demonstrates that a single person can produce enough 5-MeO-DMT to provide for large-scale demand, bypassing the need for animal-derived sources. By proving this chemical route in a lab, the goal is to shift the psychedelic community and researchers toward synthetically derived compounds. This approach ensures a stable, high-quality supply that can be easily mass-produced without harming the natural toad populations.

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Published Jan 9, 2021 · Added Mar 31, 2026