Tobias Buchborn - Research on the thalamocortical filter hypothesis of psychedelic drug action

The thalamocortical filter hypothesis of psychedelic drug action is explored using in vivo fiber photometry to examine neuronal signals in the cortex and thalamus upon administration of serotonergic psychedelics. Psychedelics are shown to induce desynchronization of glutamate release in both the prelimbic cortex and the midline thalamus. Experimental data suggests that the thalamic response precedes cortical changes, offering a new perspective on the neural mechanisms underlying the psychedelic state and challenging the notion of the cortex being the primary initiator of these effects.