Psilocybin's Effects on Extinction Learning and Distinct Reinstatement Paradigms in a Cocaine Self-Administration Model

Isis Koutrouli presents research on the anti-addictive potential of psilocybin and ibogaine using a cocaine self-administration model in rats. The study assesses the impact of these substances on extinction learning and their ability to prevent relapse. Psilocybin and ibogaine show potential in facilitating extinction learning by decreasing drug-seeking behavior and variability, resulting in more uniform responses, although they did not directly prevent drug-induced reinstatement. The research explores the neurobiological mechanisms through which these substances function, emphasizing the role of receptor modulation and neuroplasticity in potential addiction treatment.