Javier Hidalgo Jiménez - Significance of mammalian DMT: A 60-year-old debate

Javier Hidalgo Jiménez explores the contentious scientific history and potential physiological role of endogenous N,N-Dimethyltryptamine (DMT) in mammals. A long standing debate exists concerning whether this substance functions as a neurotransmitter, with past skepticism rooted in perceived low concentrations and rapid metabolism. Recent technological advancements using microdialysis have challenged these assumptions, revealing that endogenous DMT levels in specific brain regions are comparable to those of other neurotransmitters like serotonin or dopamine. Furthermore, the discussion touches upon the potential function of DMT as a neuroprotective agent against hypoxic stress, acting through specific cellular pathways, and its diverse signaling capabilities.