Simon Ruffell and Nige Netzband - Modulatory effects of ayahuasca on personality structure

Ayahuasca consumption in an adapted Shipibo setting is evaluated for its impact on personality structure, specifically focusing on the Big Five personality traits. Research findings show that ayahuasca use leads to significant, short-term reduction in neuroticism alongside increased agreeableness, both of which are sustained at a six-month follow-up. These changes correlate with the intensity of perceived mystical experiences reported by retreat participants. Beyond the psychological findings, the investigators examine the ethical implications of ayahuasca tourism in the Amazon. Concerns involve the potential for cultural appropriation, the loss of traditional knowledge, and the risks of commodification within this growing market. Research centers highlight the need for ethical conduct.