Stevens Rehen - Biological Effects of Psychedelics in Human Neural Stem Cells and Brain Organoids

Human brain organoids and stem cells provide a sophisticated model for investigating the molecular mechanisms of psychedelics. By exposing these neural tissues to compounds like harmine and N,N-DMT, scientists can better understand how these substances drive synaptogenesis and influence neuroplasticity. Specifically, harmine inhibits DYRK1A, a kinase associated with neurodegeneration, suggesting potential therapeutic applications for Alzheimer's and other neurodegenerative disorders. Psychedelics increase neurogenesis in vitro and in vivo, with observational proteomics supporting their role in cell survival and signaling. This research contrasts the fast-acting neurotrophic effects of these substances with the slower, often debilitating, latency period of conventional antidepressants. These findings offer promising avenues for developing faster, more effective treatments for mood disorders.