Marta Kaczmarczyk - Possible Side Effects of Psychedelic Substances

Psychedelic substances possess potential side effects that remain under-reported in clinical and community discourse. Depersonalization and mania-like states represent key areas of concern where adverse outcomes may occur, particularly in individuals with pre-existing stress or trauma-based coping challenges. Understanding these events involves examining the neurobiology of the nervous system and the role that specific receptors, such as 5-HT-2A, play in modulating states of anxiety and emotional response. Heightened stress responses during or after a session may lead to autonomic dysregulation, contributing to persistent states of agitation or psychological distress. Recognizing these mechanisms allows for improved support, as guiding users through difficult emotional material may mitigate the transition from a fleeting challenge into a more prolonged cycle of depersonalization or manic behavior.