Malin Uthaug - Prospective Examination of Synthetic 5-methoxy-N,N-dimethyltryptamine Inhalation

5-MeO-DMT inhalation is examined for its potential therapeutic effects on mental health, with a specific focus on inflammatory markers and psychological well-being. The study employs a naturalistic observational design, tracking eleven participants through baseline, post-session, and seven-day follow-up assessments. The findings highlight significant changes in inflammatory markers, with a notable reduction of salivary IL-6, alongside improvements in affect and mindfulness-related capacities like non-judgement. Despite the small sample size and limitations inherent to observer-based reporting, stronger correlations were observed between ego dissolution ratings and positive decreases in depression, anxiety, and stress scores at the follow-up. This research supports the potential of synthetic 5-MeO-DMT in addressing complex psychological states and trauma-related symptoms, suggesting that deeper investigation into its clinical utility and safety is warranted.