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Opioid withdrawal treatment compares baclofen with clonidine in a double-blind randomized clinical trial. Across a 14-day, double-blind study of 62 opioid dependent patients, the trial evaluates side effects at multiple time points while using baclofen up to 40 mg per day and clonidine up to 0.8 mg per day given in divided doses. The work focuses on whether baclofen matches or improves clonidine not only for withdrawal symptom management but specifically for the side effect profile during opioid detoxification.