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A clarification on MDMA research in animals reveals that commonly presented images of neuronal damage were based on high subcutaneous doses that exceed typical human use. The scientific evidence suggests that while binge use may negatively affect re-innervation patterns, responsible moderate use does not necessarily lead to long-term neurodegeneration as often portrayed in popular media. Detailed analysis of experimental studies shows that while serotonin-producing neurons can be affected by specific dosing schedules, recovery often occurs within months. The context of these studies remains important; researchers often focus on extreme dose scenarios to observe potential biological markers of stress, which do not directly map onto recreational user habits.