What Approval Won’t Solve: Brian Barnett on Ketamine’s Lessons, RVUs, and Scaling Psychedelic Care

Ketamine lessons are used to argue that regulatory approval alone will not fix the practical barriers to scaling psychedelic care. Dr. Brian Barnett, a psychiatrist at Cleveland Clinic, discusses how ketamine can help open the door for psychedelics, including the role of at home ketamine approaches. He also addresses the dual mechanism of psychedelics and whether subjective effects are necessary to achieve therapeutic outcomes. Barnett connects clinical development to healthcare delivery economics, focusing on reimbursement, RVUs, and real world treatment scaling. He also references Compass Pathways Phase 3 and partial response, and frames how to set up a psychedelic research programme to translate evidence into scalable care.